Prof. Kilian Muñiz

Catalysis

Group Leader:

Kilian Muñiz, ICREA Professor

Administrative Support:

Sorania Jiménez

Postdoctoral Researchers:

Kang Chen / Anna Sib (since April)

PhD Students:

Anastasia Tkacheva / Alexandra Eleni Bosnidou (until November) / Estefanía del Castillo Fernández / Daniel Fermin / Bafaluy Español / Thomas Lionel / Gerard Duhamel / Èric Cots Fargas / Andrea Flores (until June) / Eleni Georgiou / Aliénor Céline Jeandin (since September) / Jiayu Zhang (since October) / Jixiang Ni (since November)

Master Students:

Zoritsa Georgieva (Oct. – Nov.)

Visiting Students:

Anna Mateos (Sept. – Oct.) / Aslihan Baykal Kivilcim (Oct. – Dec.)

Erasmus Students:

Maya Panedy (July – Sept.)

Summary

The group of Prof. Muñiz deals with the discovery of new chemical transformations that provide direct access to molecules that contain nitrogen, which are key in a variety of compounds of biological and pharmaceutical interest. They have designed new hypomorphic iodine monomeric reagents that incorporate unprecedented iodine nitrogen links, resulting in a new enantioselective diaminization methodology. In addition, the group works on the expansion of the concept of halide oxidation chemistry. This research resulted in a series of amine reactions of non-functionalized C-H links catalysed by halides, providing access to nitrogenous aliphatic heterocycles not previously available.

Publications

‘Alkyliodines in High Oxidation State: Enhanced Synthetic Possibilities and Accelerated Catalyst Turn‐Over’
Bosnidou, A. E.; Muñiz, K.
Chem.: Eur. J 2019, 25 (60), 13654-13664

‘A Practical Aryliodine(I/III) Catalysis for the Vicinal Diamination of Styrenes’
Cots, E.; Flores, A.; Martín Romero, R.; Muñiz, K.
ChemSusChem. 2019, 12 (13), 3028-3031

‘1,3-Diamine Formation from an Interrupted Hofmann–Löffler Reaction: Iodine Catalyst Turnover through Ritter-Type Amination’
Duhamel, T.; Martínez, M. D.; Sideri, I. K.; Muñiz, K.
ACS Catal. 2019, 9, 7741-7745

MORE PUBLICATIONS

‘Detection of the Elusive Nitrogen‐Centered Radicals from Catalytic Hofmann‐Löffler Reactions’
Bosnidou, A. E.; Duhamel, T.; Muniz, K.
Eur. J. Org. Chem 2019

‘Intermolecular Radical C(sp3)−H Amination under Iodine Catalysis’
Bosnidou, A. E.; Muñiz, K.
Angew. Chem. Int. Ed. 2019, 58 (22), 7485-7489

‘Copper‐Catalyzed N‐F Bond Activation for Uniform Intramolecular C‐H Amination to Pyrrolidines and Piperidines’
Pérez, P. J.; Maseras, F.; Muñiz, K.; Belderrain, T.; Bafaluy, D.; Muñoz-Molina, J.M.; Funes-Ardoiz, I.; Herold, S.; de Aguirre, A. J.; Zhang, H.
Angew. Chem. Int. Ed. 2019, 58 (26), 8912-8916

‘Enantioselective Synthesis of Nicotine via an Iodine-Mediated Hofmann–Löffler Reaction’
Del Castillo, E.; Muñiz, K.
Org. Lett. 2019, 21 (3), 705-708

‘Cooperative iodine and photoredox catalysis for direct oxidative lactonization of carboxylic acids’
Duhamel, T.; Muñiz, K.
Chem. Commun. 2019, 55 (7), 933-936

‘Enantioselective Iodine(I/III) Catalysis in Organic Synthesis’
Flores, A.; Cots, E.; Bergès, J.; Muñiz, K.
Adv. Synth. Catal. 2019, 361 (1), 2-25

Projects

HalOx
Diseño de sistemas de oxidación basados en haluros para la formación de enlaces C-N
Ministerio | Ref: CTQ2017-88496-R
Proyectos I+D – Retos

CHAOS
C-H Activation in Organic Synthesis
COST-European Cooperation in Science and Technology | Ref: EU Cost Action 15106

 

Theses Supervised

Alexandra E. Bosnidou
November 22nd, 2019
Universitat Rovira i Virgili
New Methodology for C-N Bond Formation within Iodine Redox Manifold”